Neonatal Persistent Hypoglycemia: A Treatment Challenge
Deepti Thandaveshwara, Sushma Krishnegowda, Srinivasa Murthy Doreswamy, Anil Kumar Mathod Ganeshrao, Deepa Bhat
Abstract
Persistent hypoglycemia is a challenge in terms of diagnosis and management. We report a case of a neonate who presented with persistent hypoglycemia. The mother had a history of 2 neonatal deaths because of similar complaints. Laboratory investigations revealed increased levels of serum insulin and C-peptide, and hence, the neonate was treated with glucagon and diazoxide. A near-total pancreatectomy was done as the neonate did not respond to the above treatment. A genetic workup showed a mutation in the ABCC8 gene in this neonate. A better understanding of the underlying genetic causes will help in the early diagnosis and treatment of high-risk neonates and during the antenatal period also.
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