Perinatal Course in Pregnant Women With Sickle Cell Anemia and Outcomes in Neonates Born to Them
Aarti Mukeshbhai Dalwani, Sheila Gangadharan Aiyer
Abstract
Background: The incidence of sickle cell anemia (SCA) is predominantly high in the tribal population in Gujarat (India). Women with SCA develop complications during pregnancy.
Aim: To compare maternal complications observed during perinatal course in pregnant women with SCA and outcomes in neonates born to them
Materials and Methods: This prospective, observational study was conducted at a tertiary care institutional hospital from February to August 2017. The study enrolled 150 pregnant women: 75 each in the study and control groups. Pregnant women, belonging to various tribal communities, who tested positive in sickle solubility test were included in the study group. From the same communities, pregnant women who tested negative in sickle solubility test were included in the control group. Maternal and neonatal data from the beginning of the study till discharge were entered in a predesigned proforma. These data were statistically analyzed.
Results: We found that during perinatal period, the difference between packed cell volume requirement and other antenatal complications was significant between the 2 groups. There were no significant differences in the neonatal outcomes and overall well-being of neonates in both the groups. However, the neonates born to women in the study group had a longer NICU stay compared with those born to women in the control group.
Conclusion: Based on our observations, providing appropriate antenatal and intranatal care to pregnant women with SCA will help avoid perinatal complications and outcomes in their neonates.
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