Role of Modified Hematologic Scoring System and Platelet Indices in Diagnosing Neonatal Sepsis
Winson Chitra, Bugis Mardina Lubis, Olga Rasiyanti Siregar, Beby Syofiani Hasibuan, Inke Nadia Diniyanti Lubis, Selvi Nafianti
Abstract
Background: Blood culture is the gold standard for diagnosing neonatal sepsis. But it has a few disadvantages—obtaining results is time-consuming, involves a complicated technique, and often gives false positive or negative results. Modified hematologic scoring system (mHSS) and platelet indices help diagnose neonatal sepsis accurately.
Aim: To evaluate the diagnostic value of mHSS and platelet indices in the diagnosis of neonatal sepsis
Materials and Methods: This cross-sectional, analytical, observational study enrolled 95 neonates to assess the diagnostic values of mHSS, platelet indices, and blood culture tests. The neonates were subjected to complete blood test, peripheral blood smear, I/T ratio, and blood culture tests, and the results were statistically analyzed.
Results: The study results showed that of the 95 neonates, 29.5% neonates had a positive culture. After analyzing the data obtained, the mHSS ≥ 3 exhibited a sensitivity of 82.1%, a specificity of 83.6%, and area under curve (AUC) of 0.834. The analysis of platelet indices showed a sensitivity of 82.1%, a specificity of 86.6%, and AUC of 0.861. However, the combination of mHSS ≥ 3 and platelet indices increased the diagnostic value of these tests with a sensitivity of 92.9%, a specificity of 83.6%, and AUC of 0.917.
Conclusion: The combination of mHSS and platelet indices have a better diagnostic value than each of these tests individually in neonatal sepsis due to bacterial infection.
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