Utility of Serum Decorin Level in the Early Diagnosis of Preterm Premature Rupture of Membranes in Second and Third Trimester Pregnancies

Huseyin Guray Bicer, Necdet Oncu, Ecem Baltan

Abstract

Aims: To investigate whether there is a relationship between serum decorin level and the incidence of preterm premature rupture of membranes (PPROM) in the second and third trimesters of pregnancy and to analyze the biochemical changes after the diagnosis of PPROM

Materials and Methods: This was a prospective controlled study. Pregnant women aged 18 to 40 years, at 16 to 37 weeks of gestation, with singleton pregnancy, and without a history of preterm labor or PPROM in a previous pregnancy were enrolled. Totally, 70 women with a diagnosis of PPROM were included in the study group, and 70 women without a diagnosis of PPROM were included in the control group. Blood samples of all the women were collected, and the serum decorin level was calculated based on the optical density values of the serum samples, and it was reported in ng/mL.

Results: The mean serum decorin level was 14.7 ng/mL in the PPROM group and 17.5 ng/mL in the control group; the difference was not statistically significant (P = .339). A significant correlation was found between serum decorin levels and maternal BMI in both the groups (P < .05). In the PPROM group, no significant correlation was found between the latent time from sampling to delivery (P = 0.153).

Conclusion: The approach to diagnose or predict PPROM by determining the serum decorin level is not currently possible.