Alobar Holoprosencephaly With Cyclopia: A Rare Lethal Anomaly
Soniya Vishwakarma, Ramesh Chand
Abstract
Cyclopia is the most severe form of alobar holoprosencephaly and is a rare congenital craniofacial abnormality. Cyclopia is characterized by the fusion of the orbits, absence of the nose, and presence of a proboscis. Cyclopia has an unknown and varied etiology, with both genetic and environmental factors playing a role.
A 27-year-old female (G4P3L3) presented with obstructed labor. With the assistance from medical personnel, she delivered a live female neonate through cesarean section. The neonate was born with multiple defects, which was diagnosed as a rare case of holoprosencephaly with cyclopia. The neonate had a single central slitlike orbital groove, a single eye, a superiorly attached blind-ending proboscis, no nose, and a well-formed mouth. However, the neonate died soon after birth.
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